Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Stockholders' Equity

Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Preferred Stock [Member]	Common Stock [Member]	Common Shares Issuable [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Total
Balance at Dec. 31, 2020	$ 3	$ 5		$ 566,356	$ (595,797)	$ (29,433)
Balance, shares at Dec. 31, 2020	2,450	5,218
Extinguishment of debt discount upon adoption of ASU 2020-06				(4,745)	226	(4,519)
Conversion of Preferred Series J-1 to common stock	$ (2)	$ 1		1
Conversion of Preferred Series J-1 to common stock, shares	(2,354)	692
Common shares issued upon mandatory conversion of notes payable and accrued interest		$ 11	$ 1,113	37,675		38,799
Common shares issued upon mandatory conversion of notes payable and accrued interest, shares		11,086	327
Common shares issued upon exercise of warrants		$ 3		16,430		16,433
Common shares issued upon exercise of warrants, shares		3,074
Issuance of common stock in public offering, net of cost		$ 5		24,674		24,679
Issuance of common stock in public offering, net of cost, shares		4,945
Issuance of common stock for research and development agreement				1,355		1,355
Issuance of common stock for research and development agreement, shares		190
Issuance of common stock as equity compensation to consultants		$ 3		15,337		15,340
Equity compensation to consultants, shares		3,082
Issuance of common stock as equity compensation to officers, employees, and board of directors		$ 4		16,979		16,983
Equity compensation to officers, employees, and board of directors, shares		3,775
Fair value of vested stock options				251		251
Extinguishment of derivative liability				35		35
Net loss					(58,013)	(58,013)
Balance at Dec. 31, 2021	$ 1	$ 32	$ 1,113	674,348	(653,584)	21,910
Balance, shares at Dec. 31, 2021	96	32,062	327
Equity compensation to consultants, shares		527
Issuance of common stock as equity compensation to officers, employees, and board of directors		$ 1		2,521		2,522
Equity compensation to officers, employees, and board of directors, shares		710
Fair value of vested stock options				3,032		3,032
Net loss					(20,884)	(20,884)
Cancellation of common stock previously issued for services
Cancellation of common stock previously issued for services, shares		(291)
Cancellation of common stock previously issued to prior CEO		$ (2)		(222)		(224)
Cancellation of common stock previously issued to prior CEO, shares		(1,845)
Common stock issued upon conversion of notes payable			$ (1,113)	1,148		35
Common stock issued upon conversion of notes payable, shares		338	(327)
Issuance of common stock as equity compensation to consultants		$ 1		2,091		2,092
Issuance of common stock in settlement of vendor payable		$ 1		3,250		3,251
Issuance of common shares in settlement of vendors payable, shares		1,222
Balance at Dec. 31, 2022	$ 1	$ 33		$ 686,168	$ (674,468)	$ 11,734
Balance, shares at Dec. 31, 2022	96	32,723