Quarterly report pursuant to Section 13 or 15(d)

Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative)

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Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative) - USD ($)
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Dec. 31, 2016
Company And Summary Of Significant Accounting Policies Tables        
Accumulated deficit $ (279,589,000)   $ (269,499,000)  
Cash and cash equivalent $ 2,870,000 $ 235,000 $ 576,000 $ 19,000
Diluted shares excluded from calcuation of EPS 1,695,686 848,115    
Research and development $ 3,473,000 $ 144,000