Quarterly report pursuant to Section 13 or 15(d)

Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative)

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Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
Company And Summary Of Significant Accounting Policies Tables        
Accumulated deficit $ (533,195)   $ (528,685)  
Cash and cash equivalent $ 51 $ 2,870 $ 60 $ 576
Diluted shares excluded from calcuation of EPS 22,731,781 4,553,668    
Research and development $ 834 $ 3,473