Annual report pursuant to Section 13 and 15(d)

Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative)

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Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative) - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Accumulated deficit $ (145,682,000) $ (112,956,000) $ (89,467,000)
Cash and cash equivalent $ 47,000 $ 855,000 $ 43,000
Stock options granted 52,000 321,833  
Expected volatility 90.00%    
Risk free interest rate 1.50%    
Expected life 5 years    
Expected dividend yield $ 0.00    
Share based compensation expense $ 221,000 $ 162,000  
Diluted shares excluded from calcuation of EPS 12,525,721 3,092,737  
Research and development costs $ 1,000,000 $ 0  
Minimum      
Amortized over vesting period   1 year  
Maximum      
Amortized over vesting period   4 years