Quarterly report pursuant to Section 13 or 15(d)

Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative)

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Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Dec. 31, 2016
Company And Summary Of Significant Accounting Policies Tables            
Accumulated deficit $ (288,670,000)   $ (288,670,000)   $ (269,499,000)  
Cash and cash equivalent 1,096,000 $ 39,000 $ 1,096,000 $ 39,000 $ 576,000 $ 19,000
Diluted shares excluded from calcuation of EPS     1,695,686 1,030,951    
Research and development $ 3,251,000 $ 241,000 $ 6,724,000 $ 385,000