FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
BRISTOL INVESTMENT FUND LTD
   2. Issuer Name and Ticker or Trading Symbol
OXIS INTERNATIONAL INC [OXIS] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O BRISTOL CAPITAL ADVISORS, LLC, 1100 GLENDON AVE., SUITE 850		 3. Date of Earliest Transaction (Month/Day/Year)
04/04/2016
(Street)

LOS ANGELES, CA 90024		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 04/04/2016   S(1)   675,000 D $ 303,750 1,525,472 (1) D  
Common Stock 04/05/2016   J(2)   250,000 A (2) 463,806 (2) D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
BRISTOL INVESTMENT FUND LTD
C/O BRISTOL CAPITAL ADVISORS, LLC
1100 GLENDON AVE., SUITE 850
LOS ANGELES, CA 90024		     X    

Signatures

 /s/ Paul Kessler   04/05/2016
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These shares were sold by Bristol Investment Fund, Ltd., a Cayman Islands exempted company ("Bristol Investment") in a private transaction. Bristol Investment is managed by Bristol Capital Advisors LLC, a Delaware limited liability company ("BCA"). Paul Kessler, as manager of BCA, has voting and dispositive power over the shares beneficially owned by Bristol Investment. Bristol Investment owns a total of 1,525,472 shares of the Company's common stock.
(2) These shares were acquired by Bristol Capital, LLC, a Delaware limited liability company ("BC"), pursuant to an Amendment to Consulting Agreement, for services rendered by BC to the Issuer. BC's principal offices are located at 1100 Glendon Ave., Suite 850, Los Angeles, CA 90024. Paul Kessler, as manager of BC, has voting and dispositive power over the shares beneficially owned by BC.

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