Exhibit 10.21
November
11, 2020
Anthony
Cataldo
GT
Biopharma Inc.
9350
Wilshire Blvd., Suite 203
Beverly
Hills, CA 990212
Mr.
Cataldo:
This
letter is my notice of resignation as the Chief Financial Officer
and Director of GT Biopharma, Inc. effective
immediately.
Sincerely,
/s/
Steven Weldon
Steven
Weldon, MBA, CPA