UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

 
FORM 12b-25
 
Commission File Number: 000-08092
 
NOTIFICATION OF LATE FILING

 
¨ Form 10-K    ¨ Form 11-K    ¨ Form 20-F     T Form 10-Q
¨ Form N-SAR   ¨ Form N-CSR
 
For Period Ended: September 30, 2008
 
¨ Transition Report on Form 10-K        ¨ Transition Report on Form 10-Q
¨ Transition Report on Form 20-F        ¨ Transition Report on Form N-SAR
 
For the Transition Period Ended: _______________________________________
 
Nothing in this form shall be construed to imply that the Commission has verified any information contained herein.
 
If the notification relates to a portion of the filing checked above, identify the item(s) to which the notification relates: _______________________________________
________________________________________________________________________
 
PART I
REGISTRANT INFORMATION
 
Full name of registrant                                                                Oxis International, Inc.
Former name if applicable
Address of principal executive office                                       323 Vintage Park Drive, Suite B
City, state and zip code                                                               Foster City, California 94404
 
PART II
RULE 12b-25 (b) AND (c)
 
If the subject report could not be filed without unreasonable effort or expense and the registrant seeks relief pursuant to Rule 12b-25 (b), the following should be completed. (Check box if appropriate.)
 
 
 
T
 
 
(a) The reasons described in reasonable detail in Part III of this form could not be eliminated without unreasonable effort or expense;
(b) The subject annual report, semi-annual report, transition report on Form 10-K, 20-F, 11-K or Form 10-Q, or portion thereof will be filed on or before the 15th calendar day following the prescribed due date; or the subject quarterly report or transition report on Form 10-Q, or portion thereof will be filed on or before the fifth calendar day following the prescribed due date; and
(c) The accountant’s statement or other exhibit required by Rule 12b-25(c) has been attached if applicable.
 
 
 
 
PART III
NARRATIVE

 
State below in reasonable detail the reasons why Form 10-K, 11-K, 20-F, 10-Q, N-SAR or the transition report portion thereof could not be filed within the prescribed time period.
 
The compilation, dissemination and review of the information required to be presented in the Form 10-Q for the relevant fiscal year has imposed time constraints that have rendered timely filing of the Form 10-Q impracticable without undue hardship and expense to the registrant.  The registrant undertakes the responsibility to file such quarterly report no later than five days after its original date.
 
PART IV
OTHER INFORMATION

 
(1) Name and telephone number of person to contact in regard to this notification
 
Maurice Spitz                       (650) 212-2568                                                                            
        (Name)                         (Area Code)   (Telephone Number)
 
(2) Have all other periodic reports required under Section 13 or 15(d) of the Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of 1940 during the preceding 12 months or for such shorter period that the registrant was required to file such report(s) been filed?  If the answer is no, identify report(s).
 
                                                        T  Yes    ¨  No
 
(3) Is it anticipated that any significant change in results of operations from the corresponding period for the last fiscal year will be reflected by the earnings statements to be included in the subject report or portion thereof?
 
                                                         ¨ Yes     T  No
 
If so: attach an explanation of the anticipated change, both narratively and quantitatively, and, if appropriate, state the reasons why a reasonable estimate of the results cannot be made.
 
Oxis International, Inc.
Name of Registrant as Specified in Charter.
 
Has caused this notification to be signed on its behalf by the undersigned thereunto duly authorized.
 
 
Dated:  November 14, 2008                        /s/Maurice Spitz________________
        By: Maurice Spitz
        Chief Executive Officer