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                          April 23, 2021

       Anthony J. Cataldo
       Chief Executive Officer
       GT Biopharma, Inc.
       9350 Wilshire Blvd. Suite 203
       Beverly Hills, CA 90212

                                                        Re: GT Biopharma, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed April 22,
2021
                                                            File No. 333-255429

       Dear Mr. Cataldo:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Chris
Edwards at 202-551-6761 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Roger W. Bivans